What to Expect During Treatment
Before the first injection, a provider will assess whether Vivitrol can be used safely. This may include reviewing recent alcohol or opioid use, medical and mental health history, current medications, and recovery goals. Testing may be used to confirm that opioids are no longer present before treatment for opioid use disorder begins.
Vivitrol is injected into the buttock by a healthcare professional, with follow-up doses generally scheduled every four weeks. Possible side effects include injection-site discomfort, nausea, headache, dizziness, tiredness, sleep changes, or decreased appetite. Persistent or concerning effects should be discussed with the provider.
People receiving Vivitrol for opioid use disorder should know that opioid tolerance may be lower after treatment, near the end of a dosing interval, after a missed dose, or after stopping medication. Trying to overcome the opioid blockade can cause serious injury or fatal overdose.
Treatment should therefore include overdose education and a discussion about access to naloxone. Clients should also tell medical professionals that they are receiving Vivitrol, particularly when seeking emergency care, surgery, or pain treatment.